Is Jelly Force safe? Side effects and interactions

This is the one that deserves to be first, because it is the best documented and the least widely known.

A 2026 scoping review searched the peer-reviewed literature through December 2025 and found 13 publications describing 25 patients with liver injury attributed to ashwagandha, from several parts of the world. The pattern was consistent: injury developing after weeks of use, usually cholestatic or mixed rather than purely hepatocellular, commonly presenting with jaundice and itching, and usually resolving over weeks to months once the supplement was stopped. Causality assessments generally rated ashwagandha probable or likely.

The severe end of that series matters too. It included one case of acute liver failure requiring transplantation, and three deaths — all three in people who already had cirrhosis and decompensated.

The LiverTox monograph, maintained by the National Institute of Diabetes and Digestive and Kidney Diseases, covers the same subject for a clinical reader, and the NCCIH page does it for a general one. A 2026 critical review of ashwagandha's adverse effects adds gastrointestinal effects, immune hypersensitivity and endocrine disruption to the list.

The second signal from the same ingredient. A 2024 case report describes painless thyroiditis in a patient taking ashwagandha, and the 2026 meta-analysis of 23 randomised trials found a modest rise in T4 across trials, with no change in TSH or T3.

Those are two different kinds of evidence and they point the same way: this herb is not inert with respect to the thyroid. For a reader with no thyroid condition and no symptoms, a small T4 shift across trial populations is unlikely to matter. For a reader already on levothyroxine or being watched for a thyroid problem, it is a conversation to have before adding anything.

Horny goat weed is the last name on the panel and one the advertising leaves out, and it is the one with the most direct bearing on the paragraph above. Its main compound, icariin, acts on PDE5 — the enzyme sildenafil and tadalafil block.

A laboratory study using the human enzyme found icariin inhibited PDE5 with an IC50 of 5.9 micromolar, against 74 nanomolar for sildenafil: roughly eighty times weaker, in a dish. A chemically modified version matched sildenafil, and that modified compound is not what is in a supplement.

Nobody has measured what an Epimedium extract at the panel’s bound — last in the blend, so 5 mg or less — does to blood pressure, or what it adds to a prescribed PDE5 inhibitor. The concern is mechanistic, and it is worth naming anyway, because the combination it points at, a PDE5 inhibitor taken with a nitrate, can drop blood pressure dangerously.

The rest of the file is thin. LiverTox records that oral horny goat weed has not been linked to liver injury, and one published case describes a fast, irregular heart rhythm and hypomania in a man taking a horny goat weed product.

This is a safety page, so the category's own defect belongs on it. A 2025 study analysed twenty dietary supplements sold as natural sexual enhancers by high-performance liquid chromatography and found sildenafil or tadalafil — prescription drugs, unlabelled — in seven of them, at concentrations up to tens of milligrams a gram of product.

That is the mechanism by which somebody taking a nitrate and buying a natural product ends up in an emergency department. It is also the reason this desk insists on a traceable channel.

Lot JEL-26/JE-6975 and certificate reference JEL-6975-26-JE identify the production run behind the bottles sold here. Neither of those is a laboratory result and this page does not pretend otherwise — what a lot number can and cannot tell you is set out in full. What it does give you is a bottle that can be matched to an order, a seller that can be telephoned on +1 (302) 200-3480, and a returns address with a name on it. A bottle bought from a third-party marketplace listing has none of those.

Every claim in the middle column is sourced at the foot of this page.